Marcus Mariota threw for a career-high 456 yards and four touchdowns and No. 2 Oregon handed Tennessee its first loss of the season, 59-14 on Saturday.
Freshman Johnny Mundt, who replaced ailing tight end Colt Lyerla, had five catches for 121 yards and two TDs for the Ducks (3-0). Josh Huff added six catches for 125 yards and a score.
Mariota, who completed 23 of 33 passes, was the first Oregon quarterback to throw for more than 400 yards in a game since Kellen Clemens in 2005. The sophomore quarterback's yardage ties for the third-most in a game in school history.
Oregon's sloppy play at the start -- four penalties for 35 yards in the first quarter -- helped Tennessee (2-1) take an early lead, but it was fleeting and the Ducks led 38-7 at halftime.
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