Marshals raided the Cherokee County puppy mill and found the animals packed into cages.
Many of the cages were dirty and surrounded by feces. Officials said a number of the animals were underfed, had no dental care and did not have their shots.
The puppies have been nursed back to health at the Cherokee County Animal Shelter.
"A lot of them have come around where they come to you now," said Susan Garcia, the director of the shelter. "They want to be held. They know what toys are. They love all that kind of stuff now. A lot of them have made a huge turnaround, and slowly more and more of them are."
The owner of the animals, Joy Wise, agreed this week to surrender the dogs and pay the county $50,000 for their care.
She is facing 366 counts of animal cruelty and is due in court in September.
"People should come out and adopt a dog," said Mike Signorini, who visited the shelter Thursday with his son. "Adopted dogs are great dogs. That's all the dogs we've had in our family. We really enjoy having them around."
Since the raid, the shelter has been flooded with donations of pet food and other items, as well as money.
"I'm very surprised," said Garcia. "It's just been phenomenal, and it touches all of us that people think of us and think of all of the animals the way they do."
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